Using multiple sequence correlation analysis to characterize functionally important protein regions
نویسندگان
چکیده
منابع مشابه
Using multiple sequence correlation analysis to characterize functionally important protein regions.
Protein co-evolution under structural and functional constraints necessitates the preservation of important interactions. Identifying functionally important regions poses many obstacles in protein engineering efforts. In this paper, we present a bioinformatics-inspired approach (residue correlation analysis, RCA) for predicting functionally important domains from protein family sequence data. R...
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ژورنال
عنوان ژورنال: Protein Engineering Design and Selection
سال: 2003
ISSN: 1741-0126,1741-0134
DOI: 10.1093/protein/gzg053